When does Season 21 of 'Grey's Anatomy' release on Netflix? Date, cast, more (2025)

"Grey's Anatomy" is not done yet, at least not on streaming.

After a successful run on ABC, Season 21 of the longest-running primetime medical drama will be dropping on Netflix this weekend.

Season 21 of "Grey's Anatomy" picks up after a messy Season 20 finale, in which the inner turmoil between the staff at Grey Sloan Memorial Hospital is just ramping up. Catherine Fox (Debbie Allen) continues to vex her staff after Meredith Grey (Ellen Pompeo) quit to pursue her Alzheimer's disease research against orders. Meanwhile, Amelia Shepherd (Caterina Scorsone), Owen Hunt (Kevin McKidd) and Chief of Surgery Teddy Altman (Kim Raver) also realized their staff cards had been deactivated for their complicity in the secret research trial.

Season 21 will also follow up on Richard Webber's (James Pickens Jr.) decision to retire, Jo Wilson (Camila Ludington) finding out she's pregnant and the consequences of the interns standing up for Lucas Adams (Niko Terho), who may have to repeat his first year of residency after a patient's wrongful death.

Here's what to know about Season 21 of "Grey's Anatomy" before it premieres on Netflix.

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When does 'Grey's Anatomy' Season 21 come out on Netflix?

Season 21 of "Grey's Anatomy" will premiere on Saturday, June 14 at 3 a.m. ET / 12 a.m. PT on Netflix.

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How to watch 'Grey's Anatomy' Season 21

All 18 episodes of "Grey's Anatomy" Season 21 will be available to stream on Netflix on Saturday, June 14. Previous seasons of the show are available on the streaming platform as well.

Season 21 of "Grey's Anatomy" is also available to stream on Hulu and Disney+.

'Grey's Anatomy' Season 21:Stream on Hulu|Watch on Sling

When does Season 21 of 'Grey's Anatomy' release on Netflix? Date, cast, more (2)

Is Meredith Grey in 'Grey's Anatomy' Season 21?

Yes. Ellen Pompeo as Dr. Meredith Grey appears in only eight episodes of Season 21.

Pompeo, in August 2022, announced she would have a limited appearance on Season 19 and has continued to be in a small portion of seasons since. However, she continues to serve as an executive producer and offer her staple voiceover narrations in each episode.

In a recentinterview with El País, the actor said she has no plans of leaving anytime soon.

"That would make no sense," Pompeo said, per the outlet. "Emotionally or financially. The show was streamed more than a billion times in 2024. More than a billion times."

'Grey's Anatomy' Season 21 cast

When does Season 21 of 'Grey's Anatomy' release on Netflix? Date, cast, more (3)

Cast members for Season 21 of "Grey’s Anatomy" include:

  • Ellen Pompeo as Dr. Meredith Grey
  • Chandra Wilson as Dr. Miranda Bailey
  • James Pickens Jr. as Dr. Richard Webber
  • Kevin McKidd as Dr. Owen Hunt
  • Caterina Scorsone as Dr. Amelia Shepherd
  • Camila Luddington as Dr. Jo Wilson
  • Jason George as Dr. Ben Warren
  • Kim Raver as Dr. Teddy Altman
  • Jake Borelli as Dr. Levi Schmitt
  • Chris Carmack as Dr. Atticus Lincoln
  • Anthony Hill as Dr. Winston Ndugu
  • Alexis Floyd as Dr. Simone Griffith
  • Harry Shum Jr. as Dr. Benson Kwan
  • Adelaide Kane as Dr. Jules Millin
  • Midori Francis as Dr. Mika Yasuda
  • Niko Terho as Dr. Lucas Adams
  • Sophia Bush as Dr. Cass Beckman

Will 'Grey's Anatomy' return for Season 22?

Yes. "Grey's Anatomy" has been renewed for Season 22 at ABC and is expected to premiere in the fall, per a news release by the TV network.

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Contributing: Anthony Robledo, USA TODAY

Saman Shafiq is a trending news reporter for USA TODAY. Reach her at sshafiq@gannett.com and follow her on X and Instagram @saman_shafiq7.

When does Season 21 of 'Grey's Anatomy' release on Netflix? Date, cast, more (2025)
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